منابع مشابه
Codon optimality controls differential mRNA translation during amino acid starvation.
It is common wisdom that codon usage bias has evolved in the selection for efficient translation, in which highly expressed genes are encoded predominantly by optimal codons. However, a growing body of evidence suggests regulatory roles for non-optimal codons in translation dynamics. Here we report that in mammalian cells, non-optimal codons play a critical role in promoting selective mRNA tran...
متن کاملCodon Optimality Is a Major Determinant of mRNA Stability
mRNA degradation represents a critical regulated step in gene expression. Although the major pathways in turnover have been identified, accounting for disparate half-lives has been elusive. We show that codon optimality is one feature that contributes greatly to mRNA stability. Genome-wide RNA decay analysis revealed that stable mRNAs are enriched in codons designated optimal, whereas unstable ...
متن کاملGenome Landscapes and Bacteriophage Codon Usage
Across all kingdoms of biological life, protein-coding genes exhibit unequal usage of synonymous codons. Although alternative theories abound, translational selection has been accepted as an important mechanism that shapes the patterns of codon usage in prokaryotes and simple eukaryotes. Here we analyze patterns of codon usage across 74 diverse bacteriophages that infect E. coli, P. aeruginosa,...
متن کاملCorrelation between genome size, observed codon preference, and Gibbs energy of codon-anticodon interaction
The universal correspondence between the primary structure of a gene, characterized by a unique sequence of only four different nucleotide residues, and the primary structure of a protein, characterized by a given sequence of twenty different amino acid residues, is known as the "genetic code". This code is degenerated in the sense that a group of six, four or just two synonymous codons can cod...
متن کاملModal Codon Usage: Assessing the Typical Codon Usage of a Genome
Most genomes are heterogeneous in codon usage, so a codon usage study should start by defining the codon usage that is typical to the genome. Although this is commonly taken to be the genomewide average, we propose that the mode-the codon usage that matches the most genes-provides a more useful approximation of the typical codon usage of a genome. We provide a method for estimating the modal co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2016
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.353.6300.661-g